Introduction: There is significant overlap in the type of structural language impairments exhibited by children with autism spectrum disorder and children with attention deficit hyperactivity disorder. This similarity suggests that the cognitive impairment contributing to the structural language deficits in ASD and ADHD may be shared. Previous studies have speculated that procedural memory deficits may be the shared cognitive impairment. The procedural deficit hypothesis argues that language deficits can be explained by differences in the neural structures underlying the procedural memory (...) network. This hypothesis is based on the premise that the neural structures comprising the procedural network support language learning. In this study, we aimed to test the PDH in children with ASD, ADHD, and typical development.Methods: One hundred and sixty-three participants : 91 with ASD, 26 with ADHD, and 46 with TD, completed standardized measures of cognitive and language ability as well as structural magnetic resonance imaging. We compared the structural language abilities, the neural structures underlying the procedural memory network, and the relationship between structural language and neural structure across diagnostic groups.Results: Our analyses revealed that while the structural language abilities differed across ASD, ADHD, and TD groups, the thickness, area, and volume of the structures supporting the procedural memory network were not significantly different between diagnostic groups. Also, several neural structures were associated with structural language abilities across diagnostic groups. Only two of these structures, the inferior frontal gyrus, and the left superior parietal gyrus, are known to be linked to the procedural memory network.Conclusions: The inferior frontal gyrus and the left superior parietal gyrus, have well-established roles in language learning independent of their role as part of the procedural memory system. Other structures such as the caudate and cerebellum, with critical roles in the procedural memory network, were not associated with structural language abilities across diagnostic groups. It is unclear whether the procedural memory network plays a fundamental role in language learning in ASD, ADHD, and TD. (shrink)

Since January 2016, the Mahidol Oxford Tropical Medicine Research Unit has trialled a data-sharing policy where requests to access research datasets are processed through a Data Access Committee. In this paper, we share our experiences establishing data management systems and data-sharing infrastructure including a data-sharing policy, data access committee and related procedures. We identified a number of practical and ethical challenges including requests for datasets collected without specific or broad consent to data sharing and requests from pharmaceutical companies for data (...) to support drug registration applications. We also encountered significant resource constraints which required the development of appropriate human resources and infrastructure. We suggest a research agenda to promote responsible and equitable data sharing while safeguarding the rights and interests of research participants and researchers. (shrink)

STORY L, MAYFIELD‐JOHNSON S, DOWNEY LH, ANDERSON‐LEWIS C, YOUNG R and DAY P. Nursing Inquiry 2010; 17: 373–384 Getting on Target with Community Health Advisors (GOTCHA): an innovative stroke prevention projectHealth disparities along with insufficient numbers of healthcare providers and resources have created a need for effective and efficient grassroots approaches to improve community health. Community‐based participatory research (CBPR), more specifically the utilization of community health advisors (CHAs), is one such strategy. The Getting on Target with Community Health Advisors (GOTCHA) (...) project convened an interdisciplinary team to answer the call from 10 counties in the rural Mississippi Delta area of ‘The Stroke Belt’ to meet the region’s identified health needs, and to impact the health of a disparaged state. This article explores this CBPR project including the community involvement strategies, innovative CHA training curriculum, evaluation plan, and implications to healthcare professionals, particularly nurses. (shrink)

The paper examines the legal, ethical, and public policy issues involved in the Union Carbide gas leak in India which caused the deaths of over 3000 people and injury to thousands of people. The paper begins with a historical perspective on the operating environment in Bhopal, the events surrounding the accident, then discusses an international situation audit examining internal strengths and weaknesses, and external opportunities and threats faced by Union Carbide at the time of the accident. There is a discussion (...) of management of the various interests involved in international public relations and ethical issues. A review of the financial ratio analysis of the company prior and subsequent to the accident follows, then an examination of the second tragedy of Bhopal — the tragic failure of the international legal system to adequately and timely compensate victims of the accident.The paper concludes with recommendations towards public policy, as well as a call for congressional action regarding international safety of U.S. based multinational operations. (shrink)

Research funders, regulatory agencies, and journals are increasingly expecting that individual-level data from health research will be shared. Broad consent to such sharing is considered appropriate, feasible and acceptable in low- and middle-income settings, but to date limited empirical research has been conducted to inform the design of such processes. We examined stakeholder perspectives about how best to seek broad consent to sharing data from the Mahidol Oxford Tropical Medicine Research Unit, which implemented a data sharing policy and broad consent (...) to data sharing in January 2016. Between February and August 2017 qualitative data were collected at two sites, Bangkok and the Thai-Myanmar border town of Mae Sot. We conducted eighteen semi-structured interviews. We also conducted four focus group discussions with a total of nineteen people. Descriptive and thematic coding informed analysis of aspects of data sharing that are considered most important to inform participants about, and the best ways to explain complex and abstract topics relating to data sharing. The findings demonstrated that clinical trial participants prioritise information about the potential benefits and harms of data sharing. Stakeholders made multiple suggestions for clarifying information provided about data sharing on such topics. There was significant variation amongst stakeholders’ perspectives about how much information should be provided about data sharing, and it was clear that effective information provision should be responsive to the study, the study population, the individual research participant and the research context. Effectively communicating about data sharing with research participants is challenging in practice, highlighting the importance of robust and effective data sharing governance in this context. Broad consent should incorporate effective and efficient explanations of data sharing to promote informed decision-making, without impeding research participants’ understandings of key aspects of the research from which data will be shared. Further work is required to refine both the development of core information about data sharing to be provided to all research participants, and appropriate solutions for context specific-challenges arising when explaining data sharing. (shrink)

Recent years have seen educationalists turning to Emmanuel Levinas when considering the relationship between ethics and education. While it is true that Levinas never speaks of ethics in relation to the practice of classroom education, nonetheless, for Levinas, ethics is a teaching, and learning can only take place in the presence of the Other. This book considers how, within the constraints of the Irish primary school education system, teachers can develop a Levinasian approach to teaching, that affords both them and (...) the children they teach multiple opportunities throughout the school day to take up their ethical responsibility for each other as Other. Beginning from a Levinasian understanding of learning and teaching as constituting primordially relational and ethical events, and weaving the philosophies of Levinas, and the educationalists he inspires, into the approaches of philosophy with children, restorative practice, and PAX, this book suggests a unique approach to ethics in Irish primary school classrooms. The focus of this thesis, then, is on both the philosophical underpinnings that anchor teaching as a Levinasian, and a consideration of what practical approaches could be employed by the Levinasian teacher. (shrink)

Drawing on the Ideal Standards Model, the current study investigated whether the relationship events and experiences that occur on a given day in romantic relationships were associated with partner evaluations. Individuals in a current romantic relationship completed daily measures of positive and negative relationship events and experiences and partner evaluations for seven consecutive days. As hypothesized, findings demonstrated that on a given day negative relationship events and experiences were associated with evaluating partners as falling short of mate ideals, while positive (...) relationship events and experiences were associated with evaluating partners as more closely meeting ideals. The findings demonstrate the importance of the relational context in evaluations of a partner against ideal standards. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 33.3 (2000) 193-220 [Access article in PDF] Unveiling Esther as a Pragmatic Radical Rhetoric Susan Zaeske Ahasuerus, king of Persia, hosted in the courtyard of his pavilion a grand feast bountiful in royal wine. Likewise, Queen Vashti gave a feast for the women in the king's palace. On the last day of the celebration, an inebriated Ahasuerus commanded Vashti to appear wearing her crown (only (...) her crown, according to some interpretations 1 ) to show the people her beauty. She refused. Burning with anger, Ahasuerus consulted his advisors with regard to how he should respond to the affront. They concluded that not just the king, but all husbands of the kingdom had been wronged. They advised the king to depose Vashti and issue a law commanding all wives to obey their husbands. Following this advice, Ahasuerus uncrowned Vashti and selected as his new queen the beautiful Esther, who hid the fact that she was a Jew.Esther had been raised in the provinces by her cousin, Mordecai, 2 who came with her to the king's city. One day when Mordecai encountered the king's prime minister, Haman, he refused to obey the law commanding all to bow before the king's official because Haman was an infamous enemy of the Jews. Haman was so angered by Mordecai's insolence that he decided to seek revenge by destroying not just Mordecai, but all the Jews in the kingdom. After casting lots to determine the best time to approach the king, Haman obtained Ahasuerus's permission to annihilate the Jews.When he learned of the imminent execution, Mordecai put on sackcloth and ashes and made his way through the streets of Susa, wailing. Through a messenger, Mordecai bid Esther to intercede with the king on behalf of her people. She protested that doing so would be a dangerous act because approaching the king without summons was an offense punishable by death. Reminded by Mordecai that inaction on her part meant death for her people, and possibly herself, Esther resolved to beseech the king. She commanded Mordecai to gather all the Jews in the city to fast and pray for her for three days. Then, Esther pledged, "I will go to the king, even though it is against the law. And if I perish, I perish!" (Esther 4:16). [End Page 193]On the third day, Esther stood waiting in the inner courtyard of the palace, in front of the king's quarters, where he was sitting on his throne. When Ahasuerus noticed the queen, she won his favor and he extended his gold scepter. The king then said to her, "What do you want Queen Esther? What is your petition? Even if it be half of my kingdom, you may have it"(Esther 5:3). Esther did not immediately state her request, but invited the king and Haman to a banquet she would prepare for them. At the banquet, the king again invited her request. Again, she deferred, instead asking both men to another banquet.During the night between banquets, the king suffered a bout of insomnia and ordered the book of records brought to him. Ahasuerus read that Mordecai the Jew had saved his life by informing the king's guards of an assassination plot. The next day, the king asked Haman how best to honor a man for his loyalty. Thinking that Ahasuerus wished to honor him, Haman suggested that such a man should be paraded through the streets on a fine horse. To Haman's horror, he was ordered to lead a celebratory parade for his worst enemy, Mordecai.Haman was so distraught that he was almost late for the second banquet in the queen's chambers. Once all were assembled, the king repeated his offer to receive Esther's petition. She answered, "If I have obtained your favor, Your Majesty and if it please the king, let my life be granted to me at my request. And my people's at my petition! For we've been sold, I and my people, for destruction! For slaughter and annihilation... (shrink)

Political theorists have begun to re-examine claims by indigenous peoples to lands which were expropriated in the course of sixteenth-eighteenth century European expansionism. In Australia, these issues have captured public attention as they emerged in two central High Court cases: Mabo (1992) and Wik (1996), which recognize pre-existing common law rights of native title held by indigenous people prior to European contact and, in some cases, continue to be held to the present day. The theoretical significance of the two Australian (...) cases is examined and the links drawn out between the current debate about Aboriginal land rights in Australia and the wider philosophical debate about indigenous land rights, property rights, and indigenous justice as characterized by Jeremy Waldron and James Tully. Justice towards indigenous groups requires substantial acknowledgement and recognition of the values and institutions of the relevant indigenous group; yet, these values and institutions may not readily fall under the framework of existing state structures. Attempts to redress injustice towards indigenous groups which do not question the justice of existing state institutions will therefore prove to be inadequate responses to indigenous peoples' demands for substantive justice. (shrink)

Every year, like a social drinker who wants to prove to herself that she's not an alcoholic, I give up cannabis for a month. It can be a tough and dreary time - and much as I enjoy a glass of wine with dinner, alcohol cannot take its place. Some people may smoke dope just to relax or have fun, but for me the reason goes deeper. In fact, I can honestly say that without cannabis, most of my scientific research (...) would never have been done and most of my books on psychology and evolution would not have been written. Some evenings, after a long day at my desk, I'll slip into the bath, light a candle and a spliff, and let the ideas flow - that lecture I have to give to 500 people next week, that article I'm writing for New Scientist, those tricky last words of a book I've been working on for months. This is the time when the sentences seem to write themselves. Or I might sit out in my greenhouse on a summer evening among my tomatoes and peach trees, struggling with questions about free will or the nature of the universe, and find that a smoke gives me new ways of thinking about them. Yes, I know there are serious risks to my health, and I know I might be caught and fined or put in prison. But I weigh all this up, and go on smoking grass. For both individuals and society, all drugs present a dilemma: are they worth the risks to health, wealth and sanity? For me, the pay-off is the scientific inspiration, the wealth of new ideas and the spur to inner exploration. But if I end up a mental and physical wreck, I hereby give you my permission to gloat and say: "I told you so". My first encounter with drugs was a joint shared with a college friend in my first term at Oxford. This was at the tail end of the days of psychedelia and flower power - and cannabis was easy to obtain. After long days of lectures and writing essays, we enjoyed the laughter and giggling, the heightened sensations and crazy ideas that the drug seemed to let loose. Then, one night, something out of the ordinary happened - though whether it was caused by the drug, lack of sleep or something else altogether, I don't know.. (shrink)

So-called “ugly laws” were mostly municipal statutes in the United States that outlawed the appearance in public of people who were, in the words of one of these laws, “diseased, maimed, mutilated, or in any way deformed, so as to be an unsightly or disgusting object” (Chicago City Code 1881). Although the moniker “ugly laws” was coined to refer collectively to such ordinances only in 1975 (Burgdorf and Burgdorf 1975), it has become the primary way to refer to such laws, (...) which targeted the overlapping categories of the poor, the homeless, vagrants, and those with visible disabilities. Enacted and actively enforced between the American Civil War (1867) and World War I (1918), such laws and their enforcement can tell us much about the very sorts of people who were also, a generation later, subject to explicitly eugenic laws, such as sterilization legislation. And like eugenic laws and policies, such laws continue to affect the lives of people with disabilities to this day (Schweik 2011). (shrink)

Have you ever gotten chills while listening to a particularly gorgeous piece of music? Or felt a sense of calm while gazing at a painting of a serene landscape? We have experiences like those every day, but rarely stop to consider what's happening internally to cause them. In Your Brain on Art, founder of the International Arts + Mind Lab at Johns Hopkins University School of Medicine Susan Magsamen and Google designer Ivy Ross explain how, by understanding how we (...) biologically react to aesthetic experiences, we can not only heal as individuals but thrive as communities. Using the new science of neuroaesthetics, which explores our physiological reactions to art, Magsamen and Ross show us how, for instance, gardening can help a person heal from trauma or listening to a major fifth interval can snap the body out of a fight-or-flight response. Beyond enjoyment and abstraction, art can change the way we operate on a daily, practical level. And, in addition to helping each of us heal from stress, anxiety, burnout, and other malaises of modern life, neuroaesthetics can effect major change in society writ large, whether through public art murals in high-crime areas or music and dance therapy for patients experiencing neurodegenerative disorders. (shrink)

Charitable foundations are being called upon to operate in more pen and democratic ways and to involve a more diverse constituency. This unprecedented study details the inner workings of a democratically organized philanthropy, where funding decisions are made by community activists. Susan A. Ostrander spent two years doing intensive field research at the Haymarket People's Fund -- a small, Boston-based foundation. Based on a philosophy of raising and giving away money called "Change, Not Charity," the Fund makes grants to (...) local grassroots social change organizations. The world of social movement funding comes alive with Ostrander's descriptions of grantmaking and policy meetings, donor events, and the day-to-day work of the Fund staff. Within this fascinating behind-the-scenes account, Ostrander argues that the "social relations of philanthropy" are more important and more varied than previously understood. Written at a time when Haymarket was dealing with crisis, this book tells a story of organizational change as the Fund moved from an informal collective to a more formal structure; it is also the story of a struggle to build a multi-race, multi-class, gender-equal organization. Ostrander details these ongoing struggles and addresses the larger issue of how fundraising can itself be a kind of social movement organizing among the progressive people with wealth who continue to be Haymarket's main donors. (shrink)

Although research has found that long-term mindfulness meditation practice promotes executive functioning and the ability to sustain attention, the effects of brief mindfulness meditation training have not been fully explored. We examined whether brief meditation training affects cognition and mood when compared to an active control group. After four sessions of either meditation training or listening to a recorded book, participants with no prior meditation experience were assessed with measures of mood, verbal fluency, visual coding, and working memory. Both interventions (...) were effective at improving mood but only brief meditation training reduced fatigue, anxiety, and increased mindfulness. Moreover, brief mindfulness training significantly improved visuo-spatial processing, working memory, and executive functioning. Our findings suggest that 4 days of meditation training can enhance the ability to sustain attention; benefits that have previously been reported with long-term meditators. (shrink)

Even with the passage of time, the misguided motivations of highly educated, physician-participants in the genocide known as the Holocaust remain inexplicable and opaque. Typically, the physician-patient relationship inherent within the practice of medicine, has been rooted in the partnership between individuals. However, under the Third Reich, this covenant between a physician and patient was displaced by a public health agenda that was grounded in the scientific theory of eugenics and which served the needs of a polarized political system that (...) relied on this hypothesis to justify society’s racial hygiene laws. As part of the National Socialist propaganda, Adolf Hitler ominously argued that the cultural decline of Germany after World War I could largely be based on interbreeding and a “resultant drop in the racial level.” This foundational premise defined those who could be ostracized, labeled and persecuted by society, including those who were assimilated. The indoctrination and implementation of this distorted social policy required the early and sustained cooperation and leadership of the medical profession. Because National Socialism promised it could restore Germany’s power, honor and dignity, physicians embraced their special role in the repair of the state. This article will explore the imperative role, moral risks and deliberate actions of physicians who participated in the amplification process from “euthanasia” to systemic murder to medically-sanctioned genocide. A goal of this analysis will be to explore what perils today’s physicians would face if they were to experience the transitional and collective behaviors of a corrupted medical profession, or if they would, instead, have the fortitude and courage necessary to protect themselves against this collaboration. Our premise is that an awareness of history can serve as a safeguard to the conceit of political ascendency and discrimination. (shrink)

Presented as a diary of a year-long search, this book explores Sabbath-keeping from the point of view of a doubting Jew trying to make sense of what has become a quaint, obsolete practice. Although the book relies upon centuries of philosophical thought, it is accessible, direct, and often humorous, aimed at others who, like Susan Pashman, cannot blindly 'obey, ' but who demand a sensible basis for their practices. Remember the Sabbath and keep it holy. What does this mean? (...) And why is it a moral obligation, ranked high on a list of commandments that includes refraining from murder, lying, cursing, and picturing God? Ultimately, Dr. Pashman decides that 'stepping back' to an objective position--the starting point for moral conduct--is the detachment that Sabbath observance demands. A Sabbath properly observed is not just a day to unplug from technology; it is a day to attentively contemplate the lives and needs of others, to take a 'God's eye' view of the world. From time to time, the journey is paused for brief personal memoirs of Pashman's Sabbath experiences over the years. These poignant, often hilarious glimpses into her life before this quest introduce the reader to her atheist grandfather, her observant Uncle Wolfie, her sly mother-in-law, her cynical older son, and her younger son whose own children, she hopes, will continue engaging with Jewish traditions. Filled with wisdom and much humor, this is a book for both contemporary, skeptical Jews seeking to preserve personal autonomy while continuing family traditions, and also for those 'spiritual seekers' of all religions in search of the rootedness that tradition supplies, without having to engage in what they might regard as hypocrisy. (shrink)

Mindfulness and the Birth Sphere draws together and critically appraises a raft of emerging research around mindfulness in healthcare, looking especially at its relevance to pregnancy and childbirth. This is an essential read for all those interested in mindfulness in connection to pregnancy and childbirth, including midwives, doulas, doctors and birth activists, whether involved in practice, research or education.

On September 23, 1949, President Harry Truman announced that the Soviet Union had successfully detonated an atomic bomb. The news that the Soviet Union had done this came as little surprise to a number of American scientists and to some members of the intelligence community who had predicted that the Soviets would quickly acquire this advanced weapons technology. But for many Americans this news was disturbing. Truman’s announcement was taken up by, among others, a young Baptist evangelist named Billy Graham. (...) Opening a tent revival in Los Angeles just two days after the President’s report, Graham preached how the news of the Soviet bomb test had “startled the world” and launched an “arms race unprecedented in the history of the world.” President Truman, he informed his listeners, said that we “must be prepared for any eventuality at any hour….” Perhaps even more ominously he asked the crowd, “Do you know the area that is marked out for the enemy’s first atomic bomb? New York! Secondly, Chicago; and thirdly, the city of Los Angeles!” It was not only evangelical preachers who foresaw catastrophic implications from a growing arsenal of atomic weapons. (shrink)

This book presents the first full translation of the correspondence of Leo Strauss and Gerhard Krüger, showing for each the development of key and influential ideas, along with seven interpretative essays by leading Strauss scholars. During the early to mid-1930’s, Leo Strauss carried on an intense, and sometimes deeply personal, correspondence with one of the leading intellectual lights among Heidegger’s circle of recent students and younger associates. A fellow traveler in the effort to “return to Plato” and reject neo-Kantian conventions (...) of the day, Krüger was also a serious student of Rudolf Bultmann and the neo-orthodox movement in which Strauss also took an early interest. During the most intense years of their correspondence, each underwent significant intellectual development: in Krüger’s case, through a penetrating series of studies of Kant and Descartes, respectively, ultimately leading to Krüger’s conversion to Catholicism; and, in Strauss’s case, through the complex stages of what he subsequently called his “reorientation,” involving what he for the first time calls “political philosophy.” Readers interested in tracing the development of Strauss’s thoughts regarding a theological alternative that he found helpfully challenging—if not ultimately compelling—will find this correspondence to be an accessible point of entry. (shrink)

Dedication: I would like to dedicate this essay to Mort Morehouse, whose intelligence, warmth, and good humour sustains NAACI to this day. I would like, too, to dedicate this essay to Nadia Kennedy who, in her paper “Respecting the Complexity of CI,” suggests that respect for the rich non-reductive emergent memories and understandings that evolve out of participating in the sort of complex communicative interactions that we experienced at the 2012 NAACI conference requires “a turning around and looking back so (...) that we might understand it better.” Thus, though “we cannot grasp the essence of the system in some determinate way, since each description provides a limited view, and portrays some aspect of the system from a specific position inside or outside it, and at a specific point in time,” nonetheless respect requires that we try “to take different ‘snapshots’ of such systems and attempt to make sense of them.” It is as a result of this urging that the following snapshot was attempted. My thanks to Nadia for being such an inspiration, and to all the participants for making this conference such a memorable occasion. (shrink)

Approximately 62,000 people in this country await organ transplants. Ten years ago the waiting list numbered 16,000. The line gets longer every day. Up to 30% of those waiting in line will die waiting. We face a chronic shortage of organs. While demand for organs steadily increases, the number of cadaveric organ donors remains relatively constant: approximately 4,000 in 1988, and approximately 5,500 in 1997. In response to this environment of scarcity, policymakers have considered initiatives in a number of domains.

Cavendish is critical of two of the experimental sciences of her day: chemistry and microscopy. Rather than creating new things, as their practitioners claim, they produce 'hermaphroditical mixtures'. I trace this startling metaphor to the alchemical tradition and suggest how its origins can help us to understand Cavendish's position. In her view, the chemists and microscopists exaggerate their own power and creativity, and fail to recognise that human creativity belongs primarily to imagination. I show how this theme is worked out (...) in Cavendish's paired texts, Observations on Experimental Philosophy and the fictional Blazing World. (shrink)

Bioethics in the blogosphere. There is important news, and then there is important news that grabs hold of people and gets them thinking and talking: “Did you see the piece on . . . ?” “What do you think?” “What would you do?” That kind of news often has to do with bioethics. The desire to capture diverse perspectives on bioethical issues of the day led The Hastings Center to launch Bioethics Forum nearly five years ago. Greg Kaebnick, editor of (...) the Hastings Center Report, conceived of it as an online adjunct to the Report. Commentaries that would take at least a month to work their way through the Report’s production cycle could be posted immediately on Bioethics Forum. And the Forum might broaden our .. (shrink)

“Coca-cola Funds scientists Who shiFt Blame for Obesity Away from Bad Diets.” Thus began the August 9, 2015 New York Times article that alerted the public and the wider scientific community to the secret tactics the soda industry was using to protect its profits on a product known to harm health and contribute to the obesity epidemic, one of the leading public health crises of our day. Following the lead of the tobacco industry, Coca-Cola was funding leading exercise scientists to (...) promote the message that physical activity was the main solution to the obesity epidemic—a claim few obesity experts accept. The response was condemnation and a deeper appreciation of the political obstacles to regulating... (shrink)

It is well-known that Chatton is among the earliest and most vehement critics of Ockham’s theory of judgment, but scholars have overlooked the role Chatton’s criticisms play in shaping Ockham’s final account. In this paper, I demonstrate that Ockham’s most mature treatment of judgment not only contains revisions that resolve the problems Chatton identifies in his earlier theories, but also that these revisions ultimately bring his final account of the objects of judgment surprisingly close to Chatton’s own. Even so, I (...) argue that, at the end of the day, there remain significant differences between their respective analyses of the structure and intentionality of judicative states. (shrink)

This collection demonstrates the range of approaches that some of the leading scholars of our day take to basic questions at the intersection of the natural and human worlds. The essays focus on three interlocking categories: Reason stakes a bigger territory than the enclosed yard of universal rules. Nature expands over a far larger region than an eternal category of the natural. And history refuses to be confined to claims of an unencumbered truth of how things happened.

The biblical “historians,” perhaps more than their modern day counterparts, show history to be a messy, complicated affair. For all its ambivalence about power and human relationships, the book of Judges functions as a profoundly thoughtful foundation myth.

In _The Politics of Toleration in Modern Life _Susan Mendus gathers a group of distinguished public figures—philosophers, historians, lawyers, and religious leaders—to reflect on a core issue within contemporary political debate. At the close of a century that will be remembered for its two world wars and its eruptions of genocide, the contributors examine the importance of an insistence on tolerance and the dangers of its lack, both historically and in the present day. How can toleration be fostered in a (...) contentious and tightly populated world? What situations and fears have historically fed attitudes of intolerance? When and how should states intervene? The authors of these essays seek answers to such questions and examine topics such as why certain national groups are especially vulnerable to intolerance and narcissistic fantasies and how the colonial view of intolerant exploitation as an acceptable norm of behavior has been replaced by a drive toward international solidarity. The essays address religious tolerance, the role of toleration in legal contexts, the philosophical justification of tolerance, and the concept of solidarity. Ethnic identity, nationalism, the “goods of conflict,” and the treatment of refugees seeking asylum are discussed as well. While one contributor argues that a moment of genuine tolerance is achieved only when there is a cost involved in the act of tolerating another person’s way of living, another stresses that rational, communal dialogue can only take place if the state is excluded from the discussion, if conflict is recognized as valuable, and if local communities come to consensus about what behavior and discourse is intolerable. Offering an accessible and engaging commentary on the concept of tolerance, _The Politics of Toleration in Modern Life_ will interest a wide range of readers of philosophy, political science, religion, sociology, and history. _Contributors_. George Carey, Christopher Hill, Michael Ignatieff, Helena Kennedy, Alasdair MacIntyre, Susan Mendus, Julia Neuberger, Bernard Williams. (shrink)

Through a detailed analysis of ghost tales in the Ashkenazi pietistic work Sefer hasidim, Susan Weissman documents a major transformation in Jewish attitudes and practices regarding the dead and the afterlife that took place between the rabbinic period and medieval times. She reveals that a huge influx of Germano-Christian beliefs, customs, and fears relating to the dead and the afterlife seeped into medieval Ashkenazi society among both elite and popular groups. In matters of sin, penance, and posthumous punishment, the (...) infiltration of Christian notions was so strong as to effect a radical departure in Pietist thinking from rabbinic thought and to spur outright contradiction of talmudic principles regarding the realm of the hereafter. Although it is primarily a study of the culture of a medieval Jewish enclave, this book demonstrates how seminal beliefs of medieval Christendom and monastic ideals could take root in a society with contrary religious values-even in the realm of doctrinal belief. (shrink)

A natural language is an organic living thing; and meanings change as words take on new, and shed old, connotations. Recent philosophy of language has paid little attention to the growth of meaning; radical philosophers like Feyerabend and Rorty have suggested that meaning-change undermines the pretensions of science to be a rational enterprise. Thinkers in the classical pragmatist tradition, however -Peirce in philosophy of science and, more implicitly, Holmes in legal theory- both recognized the significance of growth of meaning, and (...) understood how it can contribute to the progress of science and to the adaptation of a legal system to changing circumstances. This paper develops these insights, and illustrates them by reference to the growth of meaning of "DNA" from the identification of "nuclein" to the discovery of mtDNA almost a century later, and the growth of meaning of "the establishment of religion" in the First Amendment to the U.S. Constitution from its ratification in 1791 to the present day. Arguing that the growth of meaning can indeed contribute to rationality, it also shows why narrowly formal models are inadequate both to science and to law. Un lenguaje natural es una cosa viviente orgánica, y los significados cambian a medida que las palabras adoptan nuevas connotaciones y abandonan viejas. La filosofía del lenguaje reciente ha prestado poca atención al desarrollo del significado; filósofos radicales, como Feyerabend y Rorty han sugerido que el cambio de significado socava las pretensiones de la ciencia de ser una empresa racional. Pensadores en la tradición pragmatista clásica, sin embargo -Peirce en la filosofía de la ciencia y, más implícitamente, Holmes en la teoría del Derecho- reconocieron la importancia del desarrollo del significado y comprendieron cómo éste puede contribuir al progreso de la ciencia y a la adaptabilidad de un sistema jurídico a las circunstancias cambiantes. Este trabajo desarrolla estas ideas, y las ilustra por medio de una referencia a el desarrollo del significado de "ADN" desde la identificación de la "nucleína" hasta el descubrimiento del ADN mitocondrial casi un siglo más tarde, y el desarrollo del significado de "el establecimiento de una religión" en la Primera Enmienda de la Constitución de los Estados Unidos desde su ratificación en 1791 hasta la actualidad. Argumentando que el desarrollo del significado puede contribuir mucho a la racionalidad, también muestra por qué los modelos estrechamente formales son inadecuados, tanto para la ciencia como para el Derecho. (shrink)

The pornography debate occupies a prominent site of apparent contradiction in contemporary culture: a site where the interests of cultural feminism merge with those of the far Right, where an underground enterprise becomes a major growth industry, and where forms of speculation turn alarmingly practical. Another more problematic confluence occurs as a result of this debate. That is, by juxtaposing the 1986 Final Report of the Attorney General’s Commission on Pornography and the Marquis de Sade’s 120 Days of Sodom, we (...) will see how pornography and the public discourse on pornography share the same comparative logic. An examination of such a logic shows how the pleasures of comparison—its gestures toward control, limit, and transcendence—are always balanced by its failures, even tragedies: the realization of the situated nature of all measurement, juxtaposition, subordination, and hierarchization. Thus this essay is designed to both discuss and illustrate a series of issues implicit in pornography’s predicament: the impossibility of describing desire without generating desire; the impossibility of separating form and content within the process of sublimation; and, most important, the impossibility of constructing a metadiscourse on pornography once we recognize the interested nature of all discursive practices. We cannot transcend the pornography debate, for we are in it. But by writing through it, by examining its assumptions, we can learn a great deal about the problems of representing desire and the concomitant problems of a cultural desire for unmediated forms of representation. Susan Stewart, whose most recent contribution to Critical Inquiry was “Shouts on the Street: Bakhtin’s Anti-linguistics” , is the author of two books of literary theory, Nonsense: Aspects of Intertextuality in Folklore and Literature and On Longing: Narrative of the Miniature, the Gigantic, the Souvenir, the Collection , and two books of poetry, Yellow Stars and Ice and The Hive . She is finishing a book on “crimes of writing,” of which this essay is a part, and a study of the five senses. (shrink)

In 1946, Tom Brock spent part of his summer dumping mustard gas bombs off a barge into the Atlantic Ocean. Brock was a civilian employed by the United States Army Transport Service in Charleston, South Carolina. His job was to dispose of surplus bombs and drums filled with mustard gas. Sulphur mustard, commonly called “mustard gas,” can take several forms: a liquid, a solid, or a vapour. Mustard gas, named for its mustard-like color and smell, is a vesicant that is (...) toxic to humans and causes blistering and burns, affecting the lungs, eyes, and skin. Brock recalled that he and the soldiers enjoyed watching the occasional bomb explode as it sunk into the water. “We thought it was fun,” explained Brock. “I was 18 or 19 years old. We weren’t scared. We didn’t fear any explosive. We thought we were immortal.” Later that summer he was required to guard a barge of bombs that were leaking mustard gas, which looked to him like hot molasses. Due to the known health risks, Brock was told to wear a protective suit and gas mask. However, it was a hot day so he loosened the straps around his legs. As a result, enormous blisters developed, swelling out like a balloon from his toes to his knees. His summer job was no longer fun as he experienced firsthand the health hazards of exposure to mustard gas. (shrink)

When I first agreed to undergo chemotherapy, I found myself haunted by Franz Kafka's parable “In the Penal Colony.” The grisly short story was easy to translate into language pertinent to my ominous sense of the standard treatment of advanced ovarian cancer. About to be attached to a remarkable piece of apparatus, the condemned woman tastes fear rising off her tongue as she finds herself led forward into a maze of equipment, but is assured that the machinery should go on (...) working continuously for six hours or six days. If anything were to go wrong, it would only be a small matter that could then be set right at once by the uniformed technician. So my variation began. (shrink)

Peirce’s response to the anti-metaphysical positivism of his day draws on Kant’s response to Hume, but moves beyond it, being thus a valuable resource, especially in our own post-Logical Positivist era. Kant’s legacy to Peirce was a lasting conviction that metaphysics need not be the hopelessly "airy science" Hume had pooh-poohed, but could and should become a legitimate and valuable area of investigation. Peirce's legacy to philosophy today is a distinctively plausible post-Kantian reconstruction of how this might be achieved.

If rapid growth (rap) mutants of Escherichia coli could be obtained, these might prove a valuable contribution to fields as diverse as growth rate control, biotechnology and the regulation of the bacterial cell cycle. To obtain rap mutants, a dnaQ mutator strain was grown for four and a half days continuously in batch culture. At the end of the selection period, there was no significant change in growth rate. This result means that selecting rap mutants may require an alternative strategy (...) and a number of such alternatives are discussed. (shrink)

Objectives—To assess the process involved in obtaining ethical approval for a single-centre study involving geographically dispersed subjects with an uncommon genetic disorder. Design—Observational data of the application process to 53 local research ethics committees (LRECs) throughout Wales, England and Scotland. The Multicentre Research Ethics Committee (MREC) for Wales had already granted approval. Results—Application to the 53 LRECs required 24,552 sheets of paper and took two months of the researcher's time. The median time taken for approval was 39 days with only (...) seven (13%) of committees responding within the recommended 21 days. In at least nineteen cases (36%) a subcommittee considered the application. Thirty-three committees (62%) accepted the proposal without amendments but, of the remainder, four (8%) requested changes outside of the remit of LRECs. Discussion—Difficulties still exist with the system for obtaining ethical approval for studies involving a single centre but with patients at multiple sites, as is often required for genetic observational research. As such studies differ from true multicentre studies, it may be advantageous to develop a separate and specific process of application to ensure that resources are not unnecessarily expended in the quest for ethical approval. (shrink)

An Innovative Learning Centre within a Faculty of Education provides the forum to study and give lived expression to the rhythmic workings of experience through documenting a Maker Movement Day for practicing educators. Dewey’s commitment to “the idea that there is an intimate and necessary relation between the processes of actual experience and education” is at the heart of our Maker Day.1 The contemporary Maker Movement’s emphasis on studio-based learning attends to the experiences of meaning making from within the experiences (...) themselves.2 The rootedness of this thinking across time and traditions can be traced to many interested in revealing the experiential terrain.. (shrink)

Theodor W. Adorno, one of the principal figures associated with the Frankfurt School, wrote extensively on culture, modernity, aesthetics, literature, and—more than any other subject—music. To this day, Adorno remains the single most influential contributor to the development of qualitative musical sociology which, together with his nuanced intertextual readings of musical works, gives him broad claim as a continuing force in the study of music. This long-awaited collection of twenty-seven essays represents the full range of Adorno's music writing. Nearly half (...) of the essays appear in English for the first time; all of the essays are fully annotated; and the previously translated essays have been corrected and missing text restored, making this volume the definitive resource on Adorno's musical thought. (shrink)

There is growing interest in examining dark personality traits, to better explain malevolent and self-serving behaviour patterns commonly observed in clinical and non-clinical settings. Recently, taxonomies of dark personalities have been developed, along with psychometric tools to measure and delineate between traits including psychopathy, Machiavellianism and narcissism. The extent to which these constructs are distinct or overlapping remains controversial. Psychophysiological research can improve understanding of biological mechanisms contributing to personality that may help to evaluate taxonomies. This study investigated diurnal variations (...) in salivary cortisol (on waking, cortisol awakening response, and at bedtime, over two days) and their relationship to personality traits (Short Dark Triad Scale and IPIP Mini), psychopathology (Depression, Anxiety and Stress Scale; DASS) and quality of life (WHOQOL-BREF) in a non-clinical sample (N=45, 26 females, 19 males, 18-59 years). Dark personality traits correlated with low bedtime cortisol, reduced sleep, depression and poorer quality of life. Hierarchical linear regressions analyses indicated that bedtime cortisol levels significantly accounted for variance in Psychopathy (F(1,39)=5.55, p=.02, R=.52, B=-1.81, 95% CI [-3.37-(-.26)], β=-.33, sr2=.10) and reduced sleep uniquely accounted for variance Machiavellianism (F(2,40)=5.99, p=.01, R=.48, B=1.01, 95% CI [.16-2.02], β=.34, sr2=.11). These data provide preliminary evidence that supports the cortisol hypoarousal hypothesis of Psychopathy and has identified a link between Machiavellianism, sleep-wake cycles, and chronotype. The hypoarousal hypothesis of Psychopathy contends that the hypothalamic-pituitary-adrenal axis is unresponsive to the stress of social engagement. Machiavellianism was predicted by longer days with evidence for an evening chronotype. These findings indicated that the Dark Triad traits have different underlying biological mechanisms that require further exploration. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Visual EmpireSusan Buck-Morss (bio)1 The Sovereign IconThe Question of SovereigntyJust when the nation-state appeared to be waning in significance, national sovereignty is back in the spotlight. The issue takes on special urgency in the United States, where sovereign right has been proclaimed persistently by the president in an attempt to justify policies of military aggression and violations of international and domestic law, executing these policies with disregard for traditional (...) judicial and constitutional procedures.1 Giorgio Agamben’s recently translated book State of Exception has touched off a small case of collective hysteria among American academics by claiming that by their intrinsic nature, democracies undermine themselves, that dictatorship is an ontological necessity of modern politics, and that the sovereign’s power to declare a state of emergency and with it a state exception to the law places potentially the whole world under the sign of the concentration camp.Agamben’s revelation, however, is not the scandal. It is a logical truism that something cannot be a member of its own set, that constituting power (pouvoir constituens) cannot be synonymous with constituted power (pouvoir constituent).Plato in the Timaeus described a self-eating, circular being as the first living thing in the universe–an immortal, perfectly constructed animal [image 1]. Agamben seems shocked to find that such an animal does not exist. If democracies could be self-constituting and self-reproducing, if they could realize the perfect closure of the Oroborus (snake consuming its tail), there would be no decay and no history—but also no hope, no escape from the magic circle of power that is capable of mystifying any political regime, no matter how democratically conceived. The historical event that ruptures the circle’s mythic repetition is also the possibility of a better future.Unlike both Walter Benjamin and Carl Schmitt, upon whom he relies, Agamben uses history ahistorically, in order to abstract from it a timeless ontology of power. In contrast, Benjamin is attentive to historical concreteness, as is Schmitt—this attention is their common bond. But when Benjamin criticizes the parliamentary democracy of the early Weimar Republic, it is not, as it is for Schmitt, out of yearning for a strong executive to cut through parliamentary legalism and compromise.2 Rather, it reminds twentieth-century [End Page 171] parliaments of their own violent origins. A present-day executive leader who, in using the emergency powers of his office, fails to be reminded of the historical origins of representative governments no longer feels It necessary to submit to democratic rule. Benjamin believed that the watered-down versions of democracy in his own time had become little more than bourgeois governing cliques, and for that reason, he might have appreciated Thomas Jefferson’s suggestion that every generation needs a new revolution. The sovereign who declares a state of exception would then be the citizens themselves.The question we need to ask is why Thomas Jefferson’s call for permanent revolution is not predictive of the history of democracies in modern times—why it is so difficult to cut off the head of the king so that it stays off, why popular sovereignty consistently resurrects an aura of quasi-mystical power around the sovereign figure—which since Hobbes’s Leviathan has been recognized as a human artifact, a merely mortal god [see image 2]. In a democracy where only the citizens have the legitimate right to declare a state of exception to the law, the real scandal occurs when an executive branch usurps that power and is allowed to get away with it.More than the sum of merely empirical individuals of which Hobbes’s Leviathan is composed, sovereignty is a transcendent category. The sovereign is an icon in the theological sense. He (or she) embodies an enigma—precisely the power of the collective to constitute itself. The sovereign figure as personification of the collective demonstrates the power of the visible image to close the circle between constituting and constituted power, explaining why even when the illegalities of an individual sovereign are exposed, the faith of the believer is still not shaken. As long as the circle appears closed, sovereign power remains intact; likewise, and... (shrink)

On March 12, 2009, a Sikorsky S-92A helicopter travelling to two offshore oil installations crashed into the sea about 55 km away from the coastal city of St. John’s in Newfoundland and Labrador, Canada. It sank quickly with the loss of 17 lives. There was one survivor. The article examines the circumstances of the crash to assess the effectiveness of an instrumental, business case for safety and, by extension, for corporate social responsibility. The article fills a gap in the business (...) and the management literature by adopting a qualitative, case study methodology to complement earlier, predominantly quantitative research. The study analyzes a comprehensive set of documentary data available from the offshore regulator’s public inquiry website, including many days of verbatim testimony from the industry, the union, regulators, investigators, the lone survivor and families of the deceased, in addition to written submissions and expert reports. Investigatory reports from the Transportation Safety Board of Canada and the NL Inquiry were analyzed, as were regulatory documents and media coverage. Although offshore safety has improved since the Ocean Ranger disaster in 1982, the empirical evidence in this case study adds to our understanding of how reliance on a voluntary, instrumental business case for CSR in the absence of a normative concept of CSR is likely to fail, largely because of the existence of a powerful tension between oil exploration and production and investment in safety. (shrink)

This book details the underlining philosophical approaches to ethical theories and how these can be used to structure an approach to day-to-day ethical issues, and thereby resolve them. It provides an understanding of the ethical theories which underpin decisions in health care by first laying the foundation with a philosophical framework and then going on to develop this into an examination of contemporary health care dilemmas and professional issues. Not available in the U.S.

In lieu of an abstract, here is a brief excerpt of the content:LettersMaxwell J. Mehlman, Susan R. Massey, Ronald M. Green, and Fred RosnerPhysicians and the Allocation of Scarce ResourcesMadam: We read with interest Dr. Pellegrino's commentary on our article in the December 1994 issue of the Kennedy Institute of Ethics Journal, and commend him for pointing out so well the different ways that law and ethics approach the issue of physician allocation of scarce resources.We wish to make one (...) clarification. Dr. Pellegrino states that we propose that fiduciary duties be abolished. Quite the contrary, our position is that fiduciary obligations are essential to the maintenance of trust—which we believe to be an efficient as well as an ethical element of the patient-provider relationship. If fiduciary duties are undercut, as we pointed out they are by the Oregon Medicaid legislation, then some other method of promoting trust must be established, and, as we point out in the article, it is difficult to identify what that method could be.Maxwell J. MehlmanandSusan R. MasseyThe Law Medicine CenterArter & HaddenCase Western Reserve UniversityCleveland, OHSchool of LawCleveland, OHReport of the Human Embryo Research PanelMadam: In the December 1994 issue of the Kennedy Institute of Ethics Journal, I reported on the controversy surrounding the work of the NIH Human Embryo Research Panel and the conclusions reached in its report, which was formally presented to NIH Director Harold Varmus on September 27, 1994. At that time, the report was to be reviewed by the Advisory Committee to the Director (ACD) until its next meeting in early December. I am writing to update your readers on the fate of the Panel's report.On the morning of December 2, 1994, following a previous afternoon of animated discussion, the ACD unanimously accepted the Report of the Human Embryo Research Panel. Panel members and members of the NIH staff who were present and had worked for nearly a year on the Report were gratified by this vote of confidence and by the strong support of NIH Director Harold Varmus.We had little time to enjoy this success. Within a matter of hours, the White House issued a press release in which President Clinton thanked the committee for its work and then, in a remark overruling one of the key recommendations in our report, stated: "I do not believe that federal funds should be used to support the creation of human embryos for research purposes, and I have directed that NIH not allocate any resources for such research." [End Page 83]As a Panel member and active participant in that day's events, my initial response was one of shock. I was particularly distressed that the President and his advisors chose a moment so late in the process to make their views known. Why had we worked for months, I asked, without a word of concern from the White House? Although Panel members were guided primarily by our perceptions of the ethical and scientific issues involved, some were close to the political realities of Washington and would have introduced these concerns into the Panel's deliberations.Within a matter of days, my own sense of outrage had diminished. First of all, it was clear that whatever the personal sources of the President's objections to the Panel's recommendations, this high level political intervention was inevitable. Less than a month before, on November 8, with the election of a majority House and Senate, the political environment for embryo research had changed dramatically. The previous June, 32 congressmen, most of them members of a minority Republican party, had signed a letter protesting the Panel's work. Now, one of the signers of that letter, Newt Gingrich, was destined to be Speaker of the House.Second, it became clear that the damage was not total. The President has forbidden NIH to support work involving the deliberate creation of embryos for research. Without exception, members of the Panel had come to the conclusion that some development of "research embryos" must be permitted to reduce the risks of new assisted reproductive technologies, to enhance scientific knowledge, and to develop new therapies for a range of serious diseases. All these... (shrink)

In December 1927, Alan Gregg,Associate Director of the RockefellerFoundation's Division of Medical Education, setoff from Paris on an exploratory mission toRussia. After a seventeen-day visit, Greggreturned firmly committed to improvingrelations. What did Gregg `see' in the field?Using the briefing book prepared for Gregg, histravel diaries, and his final report, thispaper analyses the social and cognitivedynamics of what became an exercise inFoundation bridge-building.

Ever want to be famous? They didn't. It just sorta happened. Playing for friends at a pizzeria one day - full-on, massive world tour the next. Insane to a power of ten. Then, right in the middle the madness, they crash and burn. The reality of life is - stuff happens... Now, their fans are asking - what is it going to take to get pop music's latest 'phenomenon' back together? Can it even be done? In the fast paced, high-pressure (...) world that is pop music, will their passion be enough to ensure that our five accidental superstars will find their way back to doing what they were so amazingly good at? This is a story of unimaginable gain, devastating loss, and the remarkable ability of five friends, to overcome it all... (shrink)

Proceedings of a forum held in Austin, Tex., on Mother's Day, 1996.

BackgroundInaccurate, false or incomplete research publications may mislead readers including researchers and decision-makers. It is therefore important that such problems are identified and rectified promptly. This usually involves collaboration between the research institutions and academic journals involved, but these interactions can be problematic.MethodsThese recommendations were developed following discussions at World Conferences on Research Integrity in 2013 and 2017, and at a specially convened 3-day workshop in 2016 involving participants from 7 countries with expertise in publication ethics and research integrity. The (...) recommendations aim to address issues surrounding cooperation and liaison between institutions and journals about possible and actual problems with the integrity of reported research arising before and after publication.ResultsThe main recommendations are that research institutions should: develop mechanisms for assessing the integrity of reported research that are distinct from processes to determine whether individual researchers have committed misconduct;release relevant sections of reports of research integrity or misconduct investigations to all journals that have published research that was investigated;take responsibility for research performed under their auspices regardless of whether the researcher still works at that institution or how long ago the work was done;work with funders to ensure essential research data is retained for at least 10 years.Journals should: respond to institutions about research integrity cases in a timely manner;have criteria for determining whether, and what type of, information and evidence relating to the integrity of research reports should be passed on to institutions;pass on research integrity concerns to institutions, regardless of whether they intend to accept the work for publication;retain peer review records for at least 10 years to enable the investigation of peer review manipulation or other inappropriate behaviour by authors or reviewers.ConclusionsVarious difficulties can prevent effective cooperation between academic journals and research institutions about research integrity concerns and hinder the correction of the research record if problems are discovered. While the issues and their solutions may vary across different settings, we encourage research institutions, journals and funders to consider how they might improve future collaboration and cooperation on research integrity cases. (shrink)